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There is a common notion that oral steroids are bad because they damage the liver and injectable steroids are good because they bypass the liverand do not damage blood vessels. While both may act in the same tissue, the action of oral steroids is different from that of orally delivered steroid. In particular, oral steroids can be absorbed only into tissues such as the gut and liver by means of a transporters like urokinase, while injectable testosterone is absorbed through blood vessels.
If a transporters becomes ineffective, it can impair an enzyme that converts testosterone into DHT, which, in turn, can damage the blood vessels as well. A significant body of research has shown that these effects may occur even when injections are used, and is therefore important to know. This research is now being conducted in labs around the world and involves comparing the effects of oral and injectable steroids in humans. It turns out that both oral and injectable steroids have significant effects on the blood vessels and liver.
Research has shown that injecting testosterone into males will significantly increase blood vessel dilation. The increased blood vessel dilation may be due to the effects of the steroid acting through the vasodilator system. DHT, on the other hand, can impair the synthesis of the endothelium lining the blood vessels, but other research has shown vasodilator effects may not be observed on either testicle.
It seems that oral steroids can increase blood vessel dilation by more than 300% for both males and females. In fact, the oral steroids such as testosterone boost the blood vessel dilation to between 6.8 and 11.1 times higher than its baseline and the body can absorb up to 600% of the injected dose from the liver.
The increase in blood vessel dilation from oral testosterone might be responsible for the effects on blood vessel blood flow seen in men, but this effect is not limited to males. One study with mice found that testosterone, which can stimulate the adrenal glands to raise blood flow to the liver, also increased the blood flow to muscles (both in animals treated with oral or injectable testosterone and in those on a drug of deprivation similar to testosterone).
Another important study on the effects of injectable steroids in humans is still in progress, but a possible link was observed between the increase in muscle blood flow seen in rodents receiving oral or injectable steroids. There appears to be a correlation between high levels of blood pressure in animals receiving injectable steroids or injections and cardiovascular disease in men.
Many of the cardiovascular problems associated with steroid abuse are secondary to increased arterial pressure, suggesting that the arterial vasoconst
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